50 Cent has once again called for the smoke with Madonna — this time poking fun at the legendary pop star’s body shape.

Taking to his Instagram on Friday (October 27), the G-Unit mogul shared a screenshot of a clip from one of Madonna’s recent performances at the O2 Arena in London alongside a clip-art pic of an ant.

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“[eyes emoji] who the fvck did this?” 50 captioned the post. “She’s rich how the hell she didn’t get it fixed [raised eyebrow emoji] I want the fvcking doctors name right now. I mean damn it man ! LOL #bransoncognac #lecheminduroi.”

Check out Fif’s latest roast below:

50 Cent and Madonna have been going back and forth at one another for quite some time. After issuing an apology to her back in December 2021 after one of his posts went too farfor which Madonna wasn’t impressed with — Fif picked up where he left off just one week later when he posted an Instagram video addressing her comments using a filter from the horror film, The Purge. 

In between snippets of Madonna’s Instagram statements, 50 Cent seemed to dismiss what she was saying by either shaking his head or quietly denying her statements. In particular he said: “Your feelings were hurt” and “you took it personally” despite Madonna saying otherwise.

He included in the caption, “The Purge begins now! hey is there an age limit for this kinda shit man, i’m asking for a friend.”

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Just one year later, 50 shared a photo of Madge sitting on a bed with her legs slightly spread apart and wearing a pair of black sunglasses, thigh high tights and a revealing Versace top.

He wrote in the caption: “I hope she didn’t make her kids take this picture. LOL at 63 somebody tell her to chill out please.” He included three additional photos of aliens, suggesting Madonna looked similar to an extraterrestrial.

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Then, in November 2022, 50 Cent poked fun at Madonna again — this time for her Hip Hop dance videos on TikTok.

The Queen of Pop has been recording various clips of herself dancing to rap songs such as Baby Keem and Kendrick Lamar’s “Vent” and GloRilla and Cardi B’s “Tomorrow 2,” and some feel she’s doing it for clout.

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Using a picture of an article by The Root calling out Madonna’s TikTok videos, Fif told his followers that he tried to warn people about the pop star.

“I told y’all grand ma was on bullshit,” 50 captioned his post. “Like a virgin at 64. LOL #bransoncognac #lecheminduroi.”